Fruitful, an ancient town on the northern frontier of Palestine, 35 miles north-east of Baalbec, and 10 or 12 south of Lake Homs, on the eastern bank of the Orontes, in a wide and fertile plain. Here Nebuchadnezzar had his head-quarters in his campaign against Jerusalem, and here also Necho fixed his camp after he had routed Josiah's army at Megiddo ( 2 Kings 23:29-35 ; 25:6,20,21 ; Jeremiah 39:5 ; 52:10 ). It was on the great caravan road from Palestine to Carchemish, on the Euphrates. It is described ( Numbers 34:11 ) as "on the eastern side of Ain." A place still called el Ain, i.e., "the fountain", is found in such a position about 10 miles distant. (See JERUSALEM .)
Source
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source-manifest/easton— Easton's Bible Dictionary (PD)